Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner

Linoleic acid (LA), an n-6 polyunsaturated fatty (PUFA), is essential for fetal growth and development. We aimed to investigate the effect of maternal postnatal high LA (HLA) diet on plasma FA composition, hepatic lipids genes involved in lipid metabolism liver adult offspring. Female rats were fed with low (LLA; 1.44% LA) or HLA (6.21% diets 10 weeks before pregnancy, during gestation/lactation. Offspring weaned at day 25 (PN25), either LLA sacrificed PN180. Postnatal decreased circulating total n-3 PUFA alpha-linolenic (ALA), while increased PUFA, arachidonic (AA) both male female Maternal leptin offspring, but not males. adiponectin significantly aspartate transaminase (AST) females downregulated cholesterol, HDL-cholesterol triglycerides mRNA expression Hmgcr offspring Cpt1a Acox1 females. Both Cyp27a1 altered concentrations, sex-specific differences that control following exposure utero.